Cell division is a fundamental process forming the basis for life itself. Each time a cell divides, it makes a complete copy of its entire genome and segregates this genome such that both daughter cells receive all the genetic information required for further growth and development. Errors in the distribution of chromosomes during mitosis lead to the production of cells with an abnormal chromosome content, which in early development lead to lethal growth defects and may later contribute to the development of cancer.

 

The Holland lab is interested in the molecular mechanisms that control accurate chromosome distribution and the role that mitotic errors play in human health and disease. Our work utilizes a combination of chemical biology, biochemistry, cell biology and genetically engineered mice to study pathways involved in mitosis and their effect on cell and organism physiology. A major focus of the group is to develop cell and animal-based models to study the role of cell division defects in genome instability and tumorigenesis. 

​

Commitment to Diversity and Inclusion

​

As members of Johns Hopkins University and of the greater scientific community, we acknowledge the harm perpetuated through systemic racism and unjust biases. The Holland laboratory is committed to providing a supportive environment in which the dimensions added by diversity of race, ethnicity, nationality, socioeconomic status, disability, religion, sex, sexual orientation, gender identity, pregnancy, and marital status are valued and celebrated. Our laboratory condemns any form of past, present or future discrimination. Our mission is to consistently provide equitable access to the highest quality education possible. In addition, we acknowledge that creativity, innovation, and synergistic learning arise from diversity of approaches, thoughts, skills, and experiences. To build an optimal learning environment, we must actively seek to build diverse research groups that emphasize respect, equity and inclusion.

​