Andrew Holland, PhD

Academic Titles: 
Assistant Professor
Appointments/Affiliations: 

Department of Molecular Biology and Genetics

Department of Oncology, Cancer Biology Program

 

MA, University of Cambridge, UK

MRes, The University of Manchester, UK

PhD, The University of Manchester, UK

Postdoc, University of California, San Diego

Biosketch: 
Lab Members:
Namesort descending Classification Email Phone
Liz Graduate Student
Phillip Research Technologist
Thao Phan Graduate Student
Selected Publications:
A new mode of mitotic surveillance. Lambrus, B.G. and Holland, A.J.*, Trends in Cell Biology 8924(17): 30014-4 (2017). [ link ] [ pdf ]
Centrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals. Levine, M.S., Bakker, B., Boeckx, B., Moyett, J., Lu, J., Vitre, B., Spierings, D.C., Lansdorp, P.M., Cleveland, D.W., Lambrechts, D., Foijer, F. and Holland, A.J. Developmental Cell 40(3): 313-22. (2017). Preview     Nature Reviews Highlight     Hopkins News Release     Science Daily   The Scientist [ link ] [ pdf ]
A USP28-53BP1-p53-p21 signaling axis arrests growth following centrosome loss or prolonged mitosis. Lambrus, B.G., Daggubati, V., Uetake, Y., Scott, P.M., Clutario, K.M., Sluder, G., Holland, A.J. Journal of Cell Biology 214:143-153. (2016). Preview     Nature Reviews Highlight [ link ] [ pdf ]
Chronic centrosome amplification without tumorigenesis. Vitre, B.*, Holland, A.J.*, Kulukian, A.*, Shoshani, O., Hirai, M., Wang, Y., Maldonado, M., Cho, T., Boubaker, J., Swing, D.A., Tessarollo, L., Evans, S.M., Fuchs, E., and Cleveland, D.W. Proc. Natl. Acad. Sci. USA 112(46):E6321-30 (2015). *equal contribution. [ link ] [ pdf ]
Epidermal development, growth control, and homeostasis in the face of centrosome amplification. Kulukian, A., Holland, A.J.*, Vitre, B.*, Naik, S., Cleveland, D.W., and Fuchs, E. Proc. Natl. Acad. Sci. USA 112(46):E6311-20 (2015). *equal contribution. [ link ] [ pdf ]
p53 protects against genome instability following centriole duplication failure. Lambrus, B.G., Uetake, Y., Clutario K.M., Daggubati, V., Snyder, M., Sluder, G., Holland, A.J. Journal of Cell Biology 210(1), 63-77. (2015). Science Daily     Hopkins News Release     Genetic Engineering and Biotechnology News [ link ] [ pdf ]
STIL binding to Plk4 activates kinase activity to promote centriole duplication. Moyer T.C., Clutario K.M., Lambrus B.G., Daggubati V., Holland A.J. Journal of Cell Biology 209(6), 863-78. (2015). JCB podcast [ link ] [ pdf ]
Polo-like kinase 4 inhibition: a strategy for cancer therapy? Holland A.J., Cleveland D.W. Cancer Cell 26(2):151-3. (2014). [ link ] [ pdf ]
Polo-like kinase 4 shapes up. Levine M.S., Holland A.J. Structure 22(8):1071-3. (2014) [ link ] [ pdf ]
The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle. Holland, A.J., Fachinetti, D., Zhu, Q., Bauer, M., Verma, I.M., Nigg, E.A., and Cleveland, D.W. Genes and Development 26, 2684-2689. (2012). [ link ] [ pdf ]
Losing balance: the origin and impact of aneuploidy in cancer. Holland, A.J. and Cleveland, D.W. EMBO Reports 13, 501-514. (2012). [ link ] [ pdf ]
Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis. Holland, A.J., Fachinetti, D., Da Cruz, S., Zhu, Q., Vitre, B., Lince-Faria M., Verma, I.M., Bettencourt-Dias, M., and Cleveland, D.W. Molecular Biology of the Cell 23, 1838-1845. (2012). [ link ] [ pdf ]
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Holland, A.J., and Cleveland, D.W. Nature Reviews Molecular Cell Biology 10, 478-487. (2009). [ link ] [ pdf ]