Tyler Moyer

Academic Titles: 
BCMB Graduate Student (2014-2019)
NSF Graduate Research Fellow
Appointments/Affiliations: 

BS, Bucknell University, PA

Current: Voyager Therapeutics

Selected Publications:
SFI1 promotes centriole duplication by recruiting USP9X to stabilize the microcephaly protein STIL. Kodani, A., Moyer, T., Chen, A., Holland, A., Walsh, C.A. and Reiter, J.F. Journal of Cell Biology 218(7): 2185-87. (2019). [ link ] [ pdf ]
PLK4 promotes centriole duplication by phosphorylating STIL to link the procentriole to the microtubule wall. Moyer, T.C. and Holland, A.J. eLIFE 8: e46054. (2019). Biomedical Picture of the Day  [ link ] [ pdf ]
Applying the auxin-inducible degradation system for rapid protein depletion in mammalian cells. Lambrus, B.G., Moyer, T.C., and Holland, A.J. Methods in Cell Biol 358(6364): 716-8. (2017). [ link ] [ pdf ]
CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis. Zitouni, S., Francia, M.E., Leal, F., Montenegro Gouveia, S., Nabais, C., Duarte, P., Gilberto, S., Brito, D., Moyer, T., Kandels-Lewis, S., Ohta, M., Kitagawa, D., Holland, A.J., Karsenti, E., Lorca, T., Lince-Faria, M., Bettencourt-Dias, M. Current Biology 26(9):1127-37. (2016). [ link ] [ pdf ]
Generation of a conditional analog-sensitive kinase in human cells using CRISPR/Cas9-mediated genome engineering. Moyer T.C., Holland A.J. Methods in Cell Biol 129:19-36. (2015). [ link ] [ pdf ]
STIL binding to Plk4 activates kinase activity to promote centriole duplication. Moyer T.C., Clutario K.M., Lambrus B.G., Daggubati V., Holland A.J. Journal of Cell Biology 209(6), 863-78. (2015). JCB podcast [ link ] [ pdf ]